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KMID : 0381019930260050513
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Korean Journal of Nutrition
1993 Volume.26 No. 5 p.513 ~ p.523
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The Changes of Body Fat Accumulation, Serum Lipis and Platelet Functions in Rat Fed the Diet Containing Different Common Oils in Korea : Seasme Oil, Perilla Oil, Rice Bran Oil and Mixed Oil
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Abstract
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In this experiment, we investigated the hypolipidemic and antithrombotic effects of rats fed diets with different common oils in Korea for different feeding periods(4 weeks or 12 weeks), using Korean sesame oil, perilla oil, rice bran oil and
mixed
oil.
W-3/w-6 ratio of each group was 0.001, 1.44, 0.05 and 0.112, respectively. P/S ratio each group was 9.65, 10.49, 10,49, 5.58 and 1.68, respectively.
@ES The results were as follows:
@EN 1) According to the age, body fat accumulation was increased.
2) Perilla oil(w-3 rich) decreased total lipid, triglyceride and total cholesterol, and increased HDL-total cholesterol ratio.
3) With regard to the compositiono of platelet fatty acids, Perilla oil increased w-3/w-6 ratio of the platelet, Perilla oil lengthened bleeding time and decreased MDM(MalonDAldehyde) formation which determined in place of Thromboxane A2(TXA2)
in
platelet. This results can suggest that linolenic acid of perilla oil seem to suppress the conversion of linoleic acid to arachldonic acid(AA 20 : 4, w-6) and elcosapentaenoic acid(DPA, 20 : 5, w-3) trannsformed from linolenic acid to suppress
the
oonversion of arachidonic acid to TXA2. Since TXA2 is platelet-aggregating and vasoconstricting agent, the reduction of TXA2 generation by platelet with increased linolenic acid intakes shows prolonged bleeding time.
In conclusion, w-3 rich perilla oil has strong hypolipidemic and antithrombotic effects by changing fatty acid profiles of the platelet.
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